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강찬우(내과학교실) Sci Rep
등록일 : 2017-10-30 오후 8:29:00       조회 : 69
첨   부 :
제1저자 강찬우(내과학교실, BK21)
교신저자 조윤희(내과학교실), 이은직(내과학교실)

Sci Rep. 2017 Oct 27ɕ(1):14192. doi: 10.1038/s41598-017-14368-y.
4-Hydroxybenzaldehyde accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes.
Kang CW1,2, Han YE1,2, Kim J1,2, Oh JH2,3, Cho YH4, Lee EJ5.

Author information
1Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Korea.2Endocrinology, Institute of Endocrine Research, College of Medicine, Yonsei University, Seoul, Korea.3Department of Biochemistry, Yonsei University, Seoul, Korea.4Endocrinology, Institute of Endocrine Research, College of Medicine, Yonsei University, Seoul, Korea. wooriminji@gmail.com.5Endocrinology, Institute of Endocrine Research, College of Medicine, Yonsei University, Seoul, Korea. EJLEE423@yuhs.ac.

Abstract
4-Hydroxybenzaldehyde (4-HBA) is a naturally occurring benzaldehyde and the major active constituent of Gastrodia elata. While recent studies have demonstrated metabolic effects of 4-HBA, little is known about the physiological role of 4-HBA in acute wound healing. Here, we investigated the effects and mechanisms of 4-HBA on acute wound healing. Using an in vitro approach, we found that 4-HBA significantly promoted keratinocyte cell migration and invasion by increasing focal adhesion kinase and Src activity. In addition, 4-HBA treatment also promoted wound healing and re-epithelialization in an in vivo excision wound animal model. Combination treatment with 4-HBA and platelet-derived growth factor subunit B homodimer showed synergistic effects in promoting wound healing. Taken together, our results demonstrated that treatment with 4-HBA promoted keratinocyte migration and wound healing in mouse skin through the Src/mitogen-activated protein kinase pathway. Therefore, 4-HBA could be a candidate therapeutic agent with the potential to promote acute wound healing.
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