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권유진 박민희 김호근(병리학교실) Oncotarget
등록일 : 2017-05-12 오후 3:00:00       조회 : 435
첨   부 :
1저자 권유진(병리학, BK21) 박민희 (병리학, BK21신진연구인력~2017.2.28), 장미(병리학)
교신저자 김호근(병리학)

Oncotarget. 2017 Apr 11. doi: 10.18632/oncotarget.17023. [Epub ahead of print]
Prognosis of stage III colorectal carcinomas with FOLFOX adjuvant chemotherapy can be predicted by molecular subtype.
Kwon Y1, Park M1, Jang M1, Yun S1, Kim WK1, Kim S2, Paik S2, Lee HJ3, Hong S3, Kim TI3, Min B4, Kim H1.

Author information
1 Departments of Pathology and BK21 for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
2 Severance Biomedical Science Institute and BK21 for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
3 Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
4 Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Abstract
Individualizing adjuvant chemotherapy is important in patients with advanced colorectal cancers (CRCs), and the ability to identify molecular subtypes predictive of good prognosis for stage III CRCs after adjuvant chemotherapy could be highly beneficial. We performed microarray-based gene expression analysis on 101 fresh-frozen primary samples from patients with stage III CRCs treated with FOLFOX adjuvant chemotherapy and 35 matched non-neoplastic mucosal tissues. CRC samples were classified into four molecular subtypes using nonnegative matrix factorization, and for comparison, we also grouped CRC samples using the proposed consensus molecular subtypes (CMSs). Of the 101 cases, 80 were classified into a CMS group, which shows a 79% correlation between the CMS classification and our four molecular subtypes. We found that two of our subtypes showed significantly higher disease-free survival and overall survival than the others. Group 2, in particular, which showed no disease recurrence or death, was characterized by high microsatellite instability (MSI-H, 6/21), abundant mucin production (12/21), and right-sided location (12/21); this group strongly correlated with CMS1 (microsatellite instability immune type). We further identified the molecular characteristics of each group and selected 10 potential biomarker genes from each. When these were compared to the previously reported molecular classifier genes, we found that 31 out of 40 selected genes were matched with those previously reported. Our findings indicate that molecular classification can reveal specific molecular subtypes correlating with clinicopathologic features of CRCs and can have predictive value for the prognosis for stage III CRCs with FOLFOX adjuvant chemotherapy.
조수지 이재면(미생물학교실) Oncotarget 2017-06-19
이유라(의생명과학부) Oncotarget 2017-05-12