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조수지 이재면(미생물학교실) Oncotarget
등록일 : 2017-06-19 오후 8:14:00       조회 : 293
첨   부 :
제1저자 박필규(미생물학교실), 조수지(미생물학교실, BK21)
교신저자 이재면(미생물학교실), 동승명(NCC)

Oncotarget. 2017 May 25. doi: 10.18632/oncotarget.18170. [Epub ahead of print]
Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis.
Park PG1, Jo SJ1,2, Kim MJ1,3, Kim HJ4, Lee JH5, Park CK6, Kim H6, Lee KY7, Kim H2,6, Park JH1, Dong SM5,8, Lee JM1,2.

Author information
1Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul, Republic of Korea.2BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.3Department of Pediatrics, Severance Hospital, Institute of Allergy, Yonsei University College of Medicine, Seoul, Republic of Korea.4Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.5Research Institute, National Cancer Center, Goyang, Republic of Korea.6Department of Pathology, Yonsei University, College of Medicine, Seoul, South Korea.7Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.8IMK Bio-Convergence R&D Center, International Vaccine Institute SNU Research Park, Seoul, Republic of Korea.

Abstract
Colorectal cancer (CRC) is one of the most dangerous types of malignant tumors, and cancer metastasis is a major factor in the failure of CRC therapy. Recently, LOXL2 (lysyl oxidase-like 2) has been shown to represent a regulator of epithelial-mesenchymal transition (EMT) in different cancer types. However, LOXL2 has not been reported to be involved in CRC metastasis. In this study, we demonstrated that LOXL2 expression is strongly correlated with the rate of CRC metastasis, it participates in the regulation of EMT-related molecule expression in CRC cells in vitro, and it is involved in migratory potential alterations. Additionally, tissue microarray analysis of CRC patients showed an increase in the probability of developing CRC distant metastasis and a decrease in the survival rate of patients with high LOXL2 expression. The results obtained in this study indicate that LOXL2 is involved in the development and progression of CRC metastasis, and therefore, its expression levels may represent a useful prognostic marker.
정승수(생리학교실) Cell Rep 2017-07-10
권유진 박민희 김호근(병리학교실) Oncotarget 2017-05-12