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정승수(생리학교실) Cell Rep
등록일 : 2017-07-10 오후 8:50:00       조회 : 196
첨   부 :
제1저자 정승수(생리학교실)
공동교신저자 정승수(생리학교실), John TR Isaac(U College London), Alan P Koretsky(NIH)

Cell Rep. 2017 Jun 27ᜟ(13):2707-2717. doi: 10.1016/j.celrep.2017.06.018.

Peripheral Sensory Deprivation Restores Critical-Period-like Plasticity to Adult Somatosensory Thalamocortical Inputs.

Chung S1, Jeong JH2, Ko S2, Yu X3, Kim YH2, Isaac JTR4, Koretsky AP5.

Author information

1Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA; Brain Korea 21 Plus Project for Medical Science, Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea. Electronic address: sschung@yuhs.ac.2Brain Korea 21 Plus Project for Medical Science, Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.3Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA; Translational Neuroimaging and Neural Control Group, High-field Magnetic Resonance Department, Max Planck Institute for Biological Cybernetics, 72076 Tü;bingen, Germany.4Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK; Department of Physiology, University of Toronto, 1 King''s Circle, Toronto, ON M5S 1A8, Canada. Electronic address: jisaac5@its.jnj.com.5Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: koretskya@ninds.nih.gov.

Abstract

Recent work has shown that thalamocortical (TC) inputs can be plastic after the developmental critical period has closed, but the mechanism that enables re-establishment of plasticity is unclear. Here, we find that long-term potentiation (LTP) at TC inputs is transiently restored in spared barrel cortex following either a unilateral infra-orbital nerve (ION) lesion, unilateral whisker trimming, or unilateral ablation of the rodent barrel cortex. Restoration of LTP is associated with increased potency at TC input and reactivates anatomical map plasticity induced by whisker follicle ablation. The reactivation of TC LTP is accompanied by reappearance of silent synapses. Both LTP and silent synapse formation are preceded by transient re-expression of synaptic GluN2B-containing N-methyl-D-aspartate (NMDA) receptors, which are required for the reappearance of TC plasticity. These results clearly demonstrate that peripheral sensory deprivation reactivates synaptic plasticity in the mature layer 4 barrel cortex with features similar to the developmental critical period.

Published by Elsevier Inc.
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