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이동하 배종원 박해정(핵의학교실) Hum Brain Mapp
등록일 : 2017-08-07 오후 4:05:00       조회 : 131
첨   부 :
제1저자 이동하(현 U Coimbra, Portugal, BK21 졸업), 배종원(핵의학교실, BK21)
교신저자 박해정(핵의학교실, BK21)

Hum Brain Mapp. 2017 Jul 21. doi: 10.1002/hbm.23738. [Epub ahead of print]
Analysis of structure-function network decoupling in the brain systems of spastic diplegic cerebral palsy.
Lee D1,2, Pae C2,3, Lee JD4, Park ES5, Cho SR5, Um MH2, Lee SK6, Oh MK3, Park HJ2,3,6,7,8.

Author information
1Faculty of Psychology and Education Sciences, University of Coimbra, Coimbra, Portugal.2BK21 PLUS Project for Medical Science, Korea.3Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.4Department of Radiology and Nuclear Medicine, International St. Mary''s Hospital, Catholic Kwandong University College of Medicine, Incheon, South Korea.5Department of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.6Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea.7Department of Cognitive Science, Yonsei University, Seoul, Republic of Korea.8Center for Systems and Translational Brain Sciences, Institute of Human Complexity and Systems Science, Yonsei University, Seoul, Republic of Korea.

Abstract
Manifestation of the functionalities from the structural brain network is becoming increasingly important to understand a brain disease. With the aim of investigating the differential structure-function couplings according to network systems, we investigated the structural and functional brain networks of patients with spastic diplegic cerebral palsy with periventricular leukomalacia compared to healthy controls. The structural and functional networks of the whole brain and motor system, constructed using deterministic and probabilistic tractography of diffusion tensor magnetic resonance images and Pearson and partial correlation analyses of resting-state functional magnetic resonance images, showed differential embedding of functional networks in the structural networks in patients. In the whole-brain network of patients, significantly reduced global network efficiency compared to healthy controls were found in the structural networks but not in the functional networks, resulting in reduced structural-functional coupling. On the contrary, the motor network of patients had a significantly lower functional network efficiency over the intact structural network and a lower structure-function coupling than the control group. This reduced coupling but reverse directionality in the whole-brain and motor networks of patients was prominent particularly between the probabilistic structural and partial correlation-based functional networks. Intact (or less deficient) functional network over impaired structural networks of the whole brain and highly impaired functional network topology over the intact structural motor network might subserve relatively preserved cognitions and impaired motor functions in cerebral palsy. This study suggests that the structure-function relationship, evaluated specifically using sparse functional connectivity, may reveal important clues to functional reorganization in cerebral palsy. Hum Brain Mapp, 2017. ©; 2017 Wiley Periodicals, Inc.
Mei-yan Wu(내과학교실) J Am Soc Nephrol 2017-08-07
조보람(생리학교실) Sci Rep 2017-08-07